Summer School

L.V.T. –Ile de Berder- 56870 LARMOR-BADEN France,

 25-31 August 2007




Biosensing with channels

Subject of the Summer School

       In nature ions and macromolecules are processed and transported through highly selective protein channels. Studying, exploiting and imitating these “secretion”, ”extrusion” and “gating” phenomena and structures open up numerous prospects of applications for detecting molecules, characterizing molecular interactions, sequencing DNA, or watching peptide folding. Combining these investigations with microfluidics setups allows for instance high throughput detection of cells and makes electrophysiology and “patch-clamp on a chip” interesting for drug screening. Complementary to biological channels, recent advances in technology allow creating artificial nanometre-sized pores in solid materials.

      The aim of the school is to teach a broad and interdisciplinary perspective of this field. It concerns interested biologists, physicists, chemists and engineers. The core program includes invited general and research talks from experts in the field. Special emphasis will be given on the outline of current developments and the discussion of promising future research directions. Participating students and postdocs will have the opportunity to present and discuss their own research in poster sessions and student seminars.



Working Program

The program will include lectures on the following topics:

-         natural channels : ion channels, mechano-sensitive channels, porins, toxins, nuclear pores, translocons,

-         natural processes of transport of ions and macromolecules : biopolymer synthesis, transport of nucleic acids through nuclear pores, infection of cells by viruses, translocation and secretion of proteins,

-         biophysics of lipid membranes, fusion, fission, poration, exo- and endocytosis,

-         chemical synthesis of artificial channels,

-         microfabrication, functionalization and use of artificial nanopores and nanotubes,

-         electrical and optical detection of the transport of molecules at the scale of one single channel,

-         proteins translocation and folding,

-         forces measurement and conformations detection by translocation,

-         physics of confined polymers,

-         lipid bilayers and channels based biosensors,

-         electronic detection of bio-macromolecules.


            One half-day will be devoted to presentations by companies working in the field of microfluidics, patch-clamp on a chip, electrophysiology, drug screening and biosensors.

            One evening of popularization of the subjects of the school will be organized.

Local Organizing Committee

Loïc Auvray and Philippe Guégan (university of Évry and CNRS), Frank Artzner (university of Rennes), Mathias Winterhalter (International University Bremen), Charlie Gosse (CNRS, Laboratoire de Photonique et Nanostructures, Marcoussis), Jérôme Mathé (university of Évry)



Confirmed speakers

Mark Akeson (Santa Cruz), Aleksei Aksimentiev (Urbana), Jean-François Allemand (ENS), Frank Artzner (Rennes),  Jan Behrends (Freiburg), Roland Benz (Würzburg), Sergey M. Bezrukov (NIH), Ulrich Bockelmann (Paris), François Chatelain (Grenoble), Alexandre Ghazi (Orsay), Jene Golovchenko (Harvard), Charlie Gosse (LPN), Eric Honoré (Nice) (to confirm), John Kasianowicz (NIST), Ulrich Keyser (Leipzig), Gildas Loussouarn (Nantes), Stefan Matile (EPFL, Lausanne), Michael Mayer (Ann Arbor), Amit Meller (Boston), Liviu Movileanu (Syracuse), Katja Nestorovitch (NIH) , N.N (LIMMS, Tokyo) (to confirm), Juan Pelta (university of Cergy and Evry), Anthony Pugsley (Institut Pasteur, Paris) (to confirm), Adrian Parsegian (NIH), Reiner Peters (Münster), Nathalie Picollet-d’Hahan (Grenoble),  Yitzhak Rabin (Bar Ilan), Ludmilla Schagina (St Petersburg), Laura Steller ( Dresden), Michel Vivaudou (Grenoble), Horst Vogel (EPFL, Lausanne), Mathias Winterhalter (IUB, Bremen), Boris Shklovskii (Minneapolis), Gerhard Schütz (Linz), Zusanna Siwy (Irvine)

Scientific committee

Chairmen: Sergey Bezrukov (National Institute of Health, USA),  Mathias Winterhalter (IUB, Germany)

Members: Roland Benz (university of Würzburg), Ulrich Bockelman (ESPCI),  François Châtelain (DSV, CEA), Alexandre Ghazi (CNRS, Orsay), Horst Vogel (Ecole Polytechnique Fédérale, Lausanne)




The school  is supported by the EU-project MRTN-CT 2005-019335 (Translocation), French Ministry of Research, CNRS, CEA, 

University of Évry, Genopole, C’nano Ile de France and Nord-Ouest, 

Conseil régional de Bretagne, Conseil général du  Morbihan and the city of Vannes (provisionnal list)